When (not) to stop a clinical trial for benefit.

اخلاق در کارآزمایی

Background: Clinical trial is the standard method to assess efficacy of a medical intervention. Because of its experimental nature, meaning that subjects are exposed to an intervention with uncertain outcome and according to historical evidences of criminal researches, clinical trial is of something of a lightning rod for ethical concerns. Ethical issues surrounding clinical trials are very per...

Effect of acceptance and commitment group therapy on benefit finding and adherence to treatment in breast cancer patients and survivors: A randomized clinical trial study

Introduction: The positive experience of life changes and the following treatment play a key role in adapting and improving breast cancer. It seems that acceptance and commitment therapy (ACT) helps this issue via facilitating acceptance and clarification of values. Therefore, the current study aimed to evaluate the effectiveness of ACT on the benefit and adherence to treatment in breast cancer...

I-27: Different Regimens for Endometrial Preparationl

Freezed embryo transfer increases the cumulative pregnancy rate, reduces costs, is relatively simple to undertake and can be accomplished in a shorter time period compared to repeated Fresh cycle. There are different protocols for endometrial preparation. Although frozen embryo replacement cycles, have been used for several years, there is no agreement about the optimal way to prepare the endom...

Pocock When ( Not ) to Stop a Clinical Trial for Benefit

Stopping guidelines for an effectiveness trial: what should the protocol specify?

BACKGROUND Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. MAIN TEXT To specify better stopping guidelines in the protocol for such trials, the clinical investigators and tria...

I-17: Should All Women with PCOS-Related Infertility Be Treated with Insulin Sensitizing Drugs?

Interest in the role of insulin sensitizing drugs (ISDs) as a means of reducing compensatory hyperinsulinemia in the hope of improving metabolic and reproductive functions in women with PCOS has grown measurably over the past decade. Metformin is believed to lower fasting serum insulin levels in insulin-resistance. For the management of ovulatory infertility in the nonobese PCOS population (BMI...